Liraglutide, a GLP-1 analogue now available for the treatment of obesity (as Saxenda) in North America, works by reducing appetite and increasing satiety, thus making it easier to lose weight and keep it off (with continuing treatment). Now, a study by Olivia Farr and colleagues, in a paper published in Diabetologia not only present data showing the presence of GLP-1 receptors in human cortex, hypothalamus and medulla, but also provide functional evidence for altered brain response to food cues. After documenting the presence of GLP-1 receptor in human brains using immunohistochemistry, the researchers conducted a randomised controlled placebo-controlled, double-blind, crossover trial in 18 individuals with type 2 diabetes who were treated with placebo and liraglutide for a total of 17 days each (0.6 mg for 7 days, 1.2 mg for 7 …
bulimia nervosa
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Infectious Pain
Because my body’s been fighting a nasty infection, I’ve been feeling run down, sleeping terribly, and really struggling to get through any physically demanding tasks. Activities that I enjoy; love even, have felt grating. I started prescription antibiotics on Friday, and when I woke up Sunday, wasn’t really expecting much in the way of motivation. I’ve been running, of course, because, if you know me, you know I will run with a severed head if I can manage it. I’ve also put in a little time into the garden each day–just not as much as I ought to at this point of the season. I know I need to step it up, but I’ve felt so below par and, this is going to sound counterintuitive, but, …